. Author manuscript; available in PMC: 2018 Nov 1.

Published in final edited form as: Bioorg Med Chem Lett. 2017 Sep 6;27(21):4925–4931. doi: 10.1016/j.bmcl.2017.09.003

Table 2.

Structures and activity of inhibitors 5i–o

Entry	K_i	IC₅₀^a^,^b

	(nM)
1.	0.029	54
2.	0.015	46
3.	0.64	nt
4.	0.55	nt
5.	0.062	5.3
6.	0.062	31
7.	0.014	2.0

Darunavir (1) exhibited K_i = 16 pM, antiviral IC₅₀ = 3 nM;

nt = not tested.