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Unenhanced T1-weighted MR brain images that were acquired before (a,c) and after six administrations of macrocyclic GBCA, gadoterate meglumine, Dotarem (b), and linear GBCA, gadopentetate dimeglumine, Magnevist (d). The observed hyperintensity is apparent in the dentate nucleus (white arrows) of the subject who underwent repeated administration of linear GBCA. Adapted from [18].
