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. 2017 Oct 18;7:13502. doi: 10.1038/s41598-017-13986-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Different phase transitions. (A) PCA of the expressed genes in the different HF development stages. (B) The number of DEGs during each transition. The distributions of DEGs with a ≥ 2-fold FPKM difference for the four transitions (Ι, II, Ш and IV). (C) Venn diagrams of the DEGs in the four transitions. (D) Venn diagrams of differentially expressed TFs from transitions Ι and Ш. The number of genes is shown in the individual specific and overlapping areas in the Venn diagrams. (E) Heatmap of the overlapping TFs from transitions Ι and Ш across the different SHF cycling phases, with the HF- higher or specific genes marked in red.