Table 1.

Inclusion criteria for the literature review.

Population	Patients with a hypersensitivity reaction to drugs administered as part of standard treatment
Study design	Retrospective and prospective case-controlled studies, randomised controlled trials
Statistical evidence	Provided statistical evidence e.g. P values, OR (95% CI) to determine the strength of the association.
HLA typing	Investigations where patient and control HLA status was determined to the protein level (high resolution typing sometimes referred to as ‘four-digit resolution’). Studies where the HLA allele were genotype within the gene itself, i.e. not using proxy SNPs.
Study date	A formal systematic review was performed covering studies with the publication year between 2000 and the time of the search (April 2014) as described in the Materials and Methods section, followed by additional semi-automated searching covering April 2014 to Aug 2015 and also 1995 to 1999 (see additional studies).