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. 2017 Oct 18;7:13494. doi: 10.1038/s41598-017-13994-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PEG10 accumulates in enchondromas but is eliminated in chondrosarcomas. (a) IHC of PEG10 in enchondroma and chondrosarcoma specimens. Normal mouse IgG was used as a negative control. EC, enchondromas (n = 7); CS-G1, grade 1 chondrosarcomas (n = 11); CS-G2, grade 2 chondrosarcomas (n = 7). Scale bar = 50 μm. (b) Summed score of the percentage and intensity of positive staining in IHC. (c) Expression of PEG10 was examined by RT-qPCR. EC (n = 6); CS-G1 (n = 5); CS-G2 (n = 6). *P < 0.05; ***P < 0.001; n.s., not significant. (d,e) Double immunofluorescence (IF) of PEG10 and p-SMAD3 or p-SMAD1/5 in enchondroma and chondrosarcoma specimens. Signals of PEG10 were detected by an anti-mouse Alexa Fluor 488 antibody (green), while p-SMADs were stained by an anti-rabbit Alexa Fluor 568 antibody (red). Scale bar = 25 μm.