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. 2017 Oct 18;7:13456. doi: 10.1038/s41598-017-13917-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Involvement of Dab2 in VEGF receptor endocytosis, regulating LSEC dedifferentiation, proliferation and migration (A) Representative SEM images of fenestrae in SK-HEP1 from NaAsO2- VEGF- siDab2-, NaAsO2 + VEGF- siDab2-, NaAsO2 + VEGF + siDab2- and NaAsO2 + VEGF + siDab2 + group in vitro. Bar = 2μm. All experiments were repeated at least three times. (B) Representative EdU staining images in SK-HEP1 groups described above in vitro. Bar = 50μm. All experiments were repeated at least three times. (C) Representative crystal violet staining images of migrated cells in SK-HEP1 groups described above. Bar = 100μm. All experiments were repeated at least three times. (D) Quantitative porosity of fenestrae in SK-HEP1 groups described above in vitro. **P < 0.01. (E) Cell numbers per field of EdU stained SK-HEP1 groups described above in vitro. **P < 0.01. (F) Cell numbers per field of crystal violet stained SK-HEP1 groups described above in vitro. **P < 0.01.