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. 2017 Oct 18;7:13442. doi: 10.1038/s41598-017-13880-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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LPS treatment promotes cleavage activation of caspase-7 in the cytoplasmic fraction of macrophages. While the presence of pro-caspase-7 in the cytoplasmic fraction decreases with high LPS concentrations in the culture media of macrophages, the presence of caspase-7 increases in parallel with an important increase of CHOP in the nuclear fraction. Lamin-B used as a control associated to the nuclear fraction, flotilin for the cytoplasmic one and β-actin as the general loading control.