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. 2017 Oct 18;7:13442. doi: 10.1038/s41598-017-13880-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Inhibition of nuclear-cytoplasmic transport modifies the internalization of oxLDL, associated with disruption of the interaction c-Myc and β-adaptin. (a) Effect of LMB treatment (4 h) on internalization of dil-fluorescent natLDL and oxLDL in macrophages. (b) Under the same conditions, ROS characterization was performed. (c) Evaluation of cell viability by the MTT assay. (d) Western blot detection of c-Jun, c-Myc and β-adaptin under the treatment with LMB, natLDL and oxLDL. (e) Characterization of β-adaptin and c-Myc interaction. (f) Effect of LPS stimulus (100 ng/ml) on the interaction c-Myc and β-adaptin, and pretreatment with α-tocopherol (300 µM). Mean values are presented (n = 6, X ± SD) *p < 0.05, **p < 0.01.