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. 2017 Oct 18;7:13428. doi: 10.1038/s41598-017-13987-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Influence of sex and neophobia on RSB. A neophobic response to white chocolate was detected by three of the four dependent measures. Habituated female mice showed a short latency to eat (a) as compared to both habituated male and non-habituated female mice. Amount consumed (c) and eating duration (d) were higher in female habituated than in male habituated or female non-habituated mice. Data are expressed as means ± SEM from 8 to 11 mice. Approaches to consume (b) were unaffected by habituation although statistical post hoc analysis displayed significant differences in the first trial between female habituated and female non-habituated mice. **P < 0.01, ***P < 0.001 or male habituated ^## P < 0.01, ^### P < 0.001, two-way RM ANOVA, Bonferroni’s post hoc test.