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. 2017 Oct 18;7:13428. doi: 10.1038/s41598-017-13987-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of AA concentration on AA-depressed RSB. The administration of AA produced changes in a concentration-dependent manner in the four endpoints analysed. Doses of 0.9% and 1.2% AA produced significant changes in latency to eat (a), approaches to eat (b), amount consumed (c), and eating duration (d). Data are expressed as means ± SEM from 7 to 20 mice. (e) Values of ED₅₀ for the behavioural parameters evaluated. Appetitive behaviours (latency to eat and approaches to eat) showed similar ED₅₀ values (ED₅₀ = 0.9%) and were higher than those obtained in consummatory behaviours (ED₅₀ = 0.7%), thus suggesting that consummatory behaviours are more sensitive to changes in AA-induced pain than appetitive behaviours. *P < 0.05, ***P < 0.001, one-way ANOVA, Bonferroni’s post hoc test.