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. 2017 Oct 18;7:13428. doi: 10.1038/s41598-017-13987-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Dose response effects of diclofenac, ibuprofen, morphine, duloxetine and caffeine on the changes in RSB observed in mice with AA-induced visceral pain. Drugs were administered 90 min after AA (30 min before the test). NSAIDs drugs ibuprofen and diclofenac significantly reversed depressive-like behaviours. Morphine, duloxetine and caffeine were ineffective at any dose tested. (a) Latency to eat, (b) approaches to eat, (c) amount consumed and (d) eating duration. Data are expressed as means ± SEM from 5 to 28 mice. *P < 0.05, **P < 0.01, ***P < 0.001, one way-ANOVA, Bonferroni’s post hoc test.