Table 1.
GO enrichment analysis of differentially expressed genes (absolute fold change ≥1.5 and Benjamini-Hochberg adjusted p-value < 0.05) in adult T. urticae females of the JP-R strain exposed to either PBO, DEF or CsA compared to adult T. urticae females treated with formulation only.
| Treatment | GO Category | Description | adjusted p-value | Subontology* |
|---|---|---|---|---|
| CsA | GO:0055085 | transmembrane transport | 0 | BP |
| CsA | GO:0016021 | integral component of membrane | 6.72E-05 | CC |
| PBO | GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | 2.68E-09 | MF |
| PBO | GO:0020037 | heme binding | 3.05E-08 | MF |
| PBO | GO:0004497 | monooxygenase activity | 3.05E-08 | MF |
| PBO | GO:0005506 | iron ion binding | 3.08E-08 | MF |
| PBO | GO:0055114 | oxidation-reduction process | 1.28E-05 | BP |
| PBO | GO:0016999 | antibiotic metabolic process | 8.83E-04 | BP |
| PBO | GO:0016758 | transferase activity, transferring hexosyl groups | 2.21E-02 | MF |
| DEF | GO:0016758 | transferase activity, transferring hexosyl groups | 2.86E-05 | MF |
| DEF | GO:0016999 | antibiotic metabolic process | 4.00E-05 | BP |
| DEF | GO:0005506 | iron ion binding | 1.45E-04 | MF |
| DEF | GO:0055114 | oxidation-reduction process | 3.43E-04 | BP |
| DEF | GO:0020037 | heme binding | 4.93E-04 | MF |
| DEF | GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | 5.10E-04 | MF |
| DEF | GO:0004497 | monooxygenase activity | 7.96E-04 | MF |
| DEF | GO:0005179 | hormone activity | 1.18E-03 | MF |
| DEF | GO:0016021 | integral component of membrane | 1.66E-03 | CC |
*BP, Biological Process; MF, Molecular Function; CC, Cellular Component.