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. 2017 Oct 18;7:13485. doi: 10.1038/s41598-017-14081-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Transcriptional response to acute maximal exercise in CON and HFD mice. (A and B) GO biological processes and (C and D) KEGG pathways enriched in CON-post and HFD-post DEG (number of genes is shown in brackets). (E) Heat map showing cluster analysis of DEG contained in the GO term skeletal muscle cell differentiation enriched in CON-post (red arrows show differentially expressed genes between CON-post vs. HFD-post). (F and G) Top 20 TFBS enriched in CON-post and HFD-post DEG. (H) Transcript levels of TFs associated with the top 20 TFBS in CON and HFD mice. (I) Representative TFBS logos found in CON and HFD mice. n = 4 muscles per group.