FIG. 1.

Redox control of dermal wound healing. Normal wound healing occurs in three overlapping phases: inflammation, proliferation, and remodeling. Progression through these phases is highly regulated and coordinated by several mechanisms, including redox signaling. Both generation and scavenging of ROS, particularly H₂O₂, are critical to normal healing. The major processes regulated by redox signaling in each phase of healing are indicated in italics. ECM, extracellular matrix; H₂O₂, hydrogen peroxide; ROS, reactive oxygen species. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars