Table 5.

Agreement Between Electrocorticography and Resting-State Functional Magnetic Resonance Imaging Sub-Classified by Epilepsy Type and Cause

	ECoG, N		N, rs-fMRI agree with ECoG, % (95% CI)	PABAK (95% CI)	Surgery, N	Seizure-free 1 year, N (%)	Seizure-free 6 months, N (%)	With >50% seizure reduction 6 months, N
Overall	40	36	90 (76–97)	0.80 (0.61–0.99)	37	20 (54)	24 (65)	31 (84)
Seizure classification
SLRE	31	28	90 (74–98)	0.81 (0.60–1)	30	18 (60)	22 (73)	27 (90)
CLRE	9	8	89 (52–99)	0.60 (0.10–1)	7	2 (29)	2 (29)	4 (57)
Fisher's exact test p-value			0.999			0.212	0.079	0.068
Primary etiology (SLRE only)
Focal cortical dysplasia	14	12	86 (57–98)	0.71 (0.35–1)	13	7 (54)	9 (69)	11 (85)
Mesial temporal sclerosis	4	4	100 (40–100)	n/a	4	3 (75)	3 (75)	4 (100)
CNS tumor	6	5	83 (39–99)	n/a	6	4 (67)	5 (83)	6 (100)
Tuberous sclerosis	3	3	100 (29–100)	n/a	3	2 (67)	2 (67)	2 (67)
Encephalitis	2	2	100 (16–100)	n/a	2	1 (50)	1 (50)	2 (100)
Congenital malformation	2	2	100 (16–100)	n/a	2	1 (50)	2 (100)	2 (100)
Fisher's exact test p-value			0.999			0.984	0.978	0.661
rs-fMRI score—type of localization of focus
(1) Sublobar	31	31	100 (89–100)	0.82 (0.72–1)	28	14 (50)	18 (64)	24 (86)
(2) Lobar	5	4	80 (28–99)	n/a	5	4 (80)	4 (80)	4 (80)
(3) Hemispheric	2	1	50 (1–99)	n/a	2	1 (50)	1 (50)	2 (100)
(4) No epileptiform anomaly	2	0	0 (0)	n/a	2	1 (50)	1 (50)	1 (50)
Fisher's exact test p-value			0.001			0.829	0.922	0.627

Seizure freedom outcome at 1 year, and also 6 months; percent with >50% reduction in seizure frequency.

CI, confidence interval; CNS, central nervous system.