Table 4.
Significant differences in FC in the PI group after CBTi compared to baseline.
| Seed | Brain region | BA | FC increased or decreased | MNI coordinate (x, y, z) | Cluster size (number of voxels) | T-score |
|---|---|---|---|---|---|---|
| Rt. thalamus | Rt. superior parietal gyrus | 7 | Decreased | 34, − 56, 68 | 61 | 5.44 |
| Lt. caudate | Lt. supramarginal gyrus | 40 | Increased | − 60, − 52, 40 | 58 | 6.33 |
| Lt. putamen | Rt. superior frontal gyrus | 6 | Decreased | 28, − 2, 50 | 56 | 7.54 |
| Lt. supplementary motor area | 6 | Decreased | − 2, 2, 58 | 54 | 6.18 | |
| Lt. pallidum | Lt. orbitofrontal cortex | 47 | Increased | − 42, 32, − 10 | 146 | 6.67 |
| Lt. hippocampus | Lt. frontal pole | 46 | Increased | − 38, 52, 14 | 113 | 7.01 |
| Lt. supramarginal gyrus | 40 | Increased | − 56, − 38, 44 | 51 | 6.77 | |
| Rt. Paracingulate | 32 | Increased | 6, 20, 50 | 50 | 4.83 | |
| Lt. amygdala | Lt. lingual gyrus | 18 | Decreased | − 12, − 50, − 4 | 61 | 5.83 |
The threshold was set at an uncorrected peak-level of P < 0.001 and a whole-brain, false discovery rate-corrected cluster level of q < 0.05. FC: functional connectivity; BA: Brodmann area; MNI: Montreal Neurological Institute; Rt.: right, Lt.: left.