Table 1.

Key Time Points Associated with Collagen Gelation

Average Time (min ± SD)
	$t_{\text{LAG}}$	$t_{\text{ARR}}^{\text{CRM}}$	$t_{\text{CO}}^{\text{RHEO}}$	$t_{\text{INF}}$	$t_{\text{GEL}}^{\text{RHEO}}$	$t_{\text{INC}}^{\text{CFM}}$	$t_{\text{PL}}$
rCFM	6.3 ± 0.6	—	—	11.2 ± 1.1	—	17.1 ± 1.7a	16.1 ± 2.2
rCRM	6.3 ± 1.2	8.7 ± 0.6b	—	11.5 ± 1.1	—	—	16.8 ± 2.0
ICRM	7.5 ± 1.1	—	—	13.1 ± 1.2	—	—	19.7 ± 1.4
df,slice	2.0 ± 1.1	—	—	8.9 ± 1.1	—	—	15.6 ± 1.5
GRHEO	—	—	10.6 ± 1.1	—	12.3	—	—

Mean ± SD of nine samples monitored with confocal rheology during fibrillogenesis of 1.0 mg/mL collagen at 25°C. All data were obtained from curves indicated in the leftmost column unless otherwise noted, with r^CFM and r^CRM as the CFM and CRM image correlation curves, I^CRM as the CRM intensity curve, d_f,slice as the CRM fractal dimension, and G^RHEO as the rheological storage modulus curve. t_LAG, t_INF, and t_PL correspond to lag, inflection, and plateau time points at which the curves rise to 5, 50, and 95% of their final value, respectively. $t_{\text{CO}}^{\text{RHEO}}$ is the crossover time and $t_{\text{GEL}}^{\text{RHEO}}$ is the gel point extracted from frequency dependent rheology. The p values obtained from two-tailed, unequal variance t-tests comparing all time points are provided in the Supporting Material and Table S4.

^a$t_{\text{INC}}^{\text{CFM}}$ is the time at which oligomeric structures are fully incorporated into fibrillar structures and was extracted from CFM video data.

^b$t_{\text{ARR}}^{\text{CRM}}$ is the time at which fibrillar structures are apparently fixed in position and was extracted from CRM video data.