Table 11.

Characteristics of participants in included observational studies

Reference	Country	Male sex	Age	Comorbidity	Number of coincident medications	Functional status/frailty level	Cognitive status
Burton 2006 [48]	Scotland	51%	Mean age 77 years, subgroup analysis age ≥ 75 years	Not reported	Not reported	Not reported	Not reported
Sam 2004 [59]	USA	49.8%	Men: mean age 72.5 years. Women: mean age 79 years, 100% older than 65 years	ASA/warfarin/none: congestive heart failure 14%/22%/65%, previous myocardial infarction 20%/18%/62%, stroke 25%/28%/46%, diabetes mellitus 25%/23%/53%, hypertension 21%/21%/58%, alcohol use 19%/26%/55%	Not reported	Not reported	Not reported

Note: ACE angiotensin-converting-enzyme, ASA acetylsalicylic acid, AT Angiotensin, NSAID nonsteroidal anti-inflammatory drugs