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. 2017 Oct 17;113(8):1893–1906. doi: 10.1016/j.bpj.2017.08.036

Figure 7.

Figure 7

Another reduction of the Lipniacki model starting from the same network as in Fig. 6A leading to a different adaptive mechanism. The corresponding parameter reduction steps are given in the Supporting Material. (A) Initial biochemical reduction suppresses the positive feedback loop in a similar way (compare with Fig. 6B). (B) Symmetry breaking breaks proofreading cascades and isolates different adaptive and kinetic modules (compare with Fig. 6D). FINAL panel shows behavior of Eqs. 35–43 in the Supporting Material (full system is given, including local mass conservation). To see this figure in color, go online.