Table 1.
Tocopherols and metabolites levels in serum and colon tissues of male hCYP1A mice.
| Diet Group | α-T | γ-T | δ-T | α-CEHC | γ-CEHC | δ-CEHC | α-CMBHC | γ-CMBHC | δ-CMBHC |
|---|---|---|---|---|---|---|---|---|---|
| Serum Concentrations (μmol/L)† | |||||||||
| Control | 9.40±2.36 | 0.17±0.09 | 0.28±0.14 | 0.24±0.03 | 0.05±0.00 | 0.04±0.00 | 0.97±0.20 | 0.06±0.00 | 0.06±0.00 |
| 0.2% δ-T | 8.80±5.32 | 0.15±0.02 | 0.70±0.02a | 0.07±0.00b | 0.05±0.00 | 1.41±0.87a | 1.21±0.85 | 0.06±0.00 | 3.28±2.60a |
| Control | 8.93±1.95 | 1.05±0.18 | 0.22±0.06 | – | – | – | – | – | – |
| 0.2% γ-T | 8.37±0.92 | 2.83±0.66a | 0.10±0.03b | – | – | – | – | – | – |
| 0.2% α-T | 34.93±6.24a | 0.64±0.29 | 0.16±0.04 | – | – | – | – | – | – |
| Colon Tissues Concentrations (μmol/kg)† | |||||||||
| Control | 16.12±3.04 | 0.24±0.04 | 0.36±0.08 | 0.10±0.06 | 0.59±0.50 | 1.24±0.33 | 0.80±0.20 | 1.03±1.00 | 0.29±0.26 |
| 0.2% δ-T | 18.85±2.87 | 0.26±0.03 | 5.03±1.32a | 0.84±0.12a | 0.62±0.14 | 26.8±6.3a | 0.80±0.24 | 1.31±0.50 | 49.0±20.6a |
| Control | 22.51±2.55 | 0.54±0.10 | 0.36±0.03 | – | – | – | – | – | – |
| 0.2% γ-T | 21.09±1.82 | 8.90±1.48a | 0.20±0.06b | – | – | – | – | – | – |
| 0.2% α-T | 76.86±8.45a | 1.05±0.44 | 0.40±0.06 | – | – | – | – | – | – |
†
Value expressed as mean ± SD (n=4–5).
a
Significantly increased from the control diet group (two-tailed Student’s t-test, p<0.05).
b
Significantly decreased from the control diet group (two-tailed Student’s t-test, p<0.05).
–
, not determined; CEHC, carboxyethyl hydroxychroman; CMBHC, carboxymethylbutyl hydroxychroman.