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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Wiley Interdiscip Rev RNA. 2017 Aug 7;8(6):10.1002/wrna.1430. doi: 10.1002/wrna.1430

Figure 5. Comparison of the wing 2 motifs and interdomain linkers in LARPs.

Figure 5

A) Sequence alignment focusing on LaM wing 2, interdomain linker and the beginning of RRM1 of LARPs. Human (Hs) La sequence was aligned with 32 LARPs as for figure 4. Black vertical rectangles indicate conserved signatures characterizing wing 2; the dark red horizontal arrows denote the beginning of RRM1 strand β1 determined experimentally for human La, LARP7, LARP6 and LARP4 (9, 107, 110, IC-G & MRC, unpublished). The potential extent of the variable linker regions is indicated with a dotted line above the sequences. B, C) Close-up views of the wing 2 region of hLa superimposed with hLARP7 (B) and hLARP6 (C). Selected residues involved in the interaction of wing 2 with the rest of the domain are highlighted as sticks. hLa (PDB 2VOS) is depicted in yellow, hLARP7 in light orange (PDB 4WKR) and hLARP6 in cyan (PDB 2MTF).