Figure 2.

Correlation of evolutionary Hamiltonian energy, $E_{\text{EH}}$, with protein stability. (A) Distribution of $E_{\text{EH}}$ of experimentally characterized stable (blue) and unstable (red) sequences of the WW domain. (B) Estimated entropy of sequences (on a log scale) along $E_{\text{EH}}$, obtained by Monte Carlo simulation. The green line is the approximate threshold of $E_{\text{EH}}$ separating the stable and unstable sequences of the WW domain. To see this figure in color, go online.