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. 2017 Oct 17;113(8):1845–1857. doi: 10.1016/j.bpj.2017.09.015

Figure 3.

Figure 3

KIF3CC accelerates the rate parameter for catastrophe but not MT elongation. (A) Plot of the rate parameter for MT catastrophe plotted as a function of KIF3CC concentration from 0 to 50 nM dimer. Each data point reports the rate parameter determined by the gamma fit of the PDF plot for MT lifetime data. The nonlinear least-squared fit is shown, which provides a maximum rate of accumulation of MT aging steps. See also Fig. 2D for N values of each data point. All data are shown mean ± SE. (B) Rate of growth at the MT plus-end (nm/s) in the dynamic MT assay at 37°C for 10 min as determined from kymograph analysis, plotted as a function of KIF3CC dimer concentration. Error bars represent mean ± SE. See also Table 1 for calculated rates and N values for each condition.