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. 2017 Oct 17;113(8):1845–1857. doi: 10.1016/j.bpj.2017.09.015

Table 2.

The Mechanism Employed by KIF3CC Is Distinct from Other Catastrophe Factors

MCAK (Kinesin-13)a Kip3/KIF18A (Kinesin-8)b KIF3CC (Kinesin-2)
MT tip localization tip recognition yes yes yes
motility bilateral diffusion processivity no
plus-end targeting no yes yes
Mechanism of influencing MT dynamics catastrophe factor yes yes yes
structural features curls protofilaments detects curved subunits eliminates tip taper
method of MT disassembly catastrophe depolymerization by cooperative removal of subunits catastrophe
Impact on MT aging change number of MT aging steps decreases no change decreases
rate of catastrophe no impact accelerates accelerates
Rescue events no no no
a

Summarized MCAK results from (17, 29, 34, 35, 36, 38, 39, 40).

b

Summarized Kip3/KIF18A results from (17, 21, 28, 33, 37).