Table 2.
MCAK (Kinesin-13)a | Kip3/KIF18A (Kinesin-8)b | KIF3CC (Kinesin-2) | ||
---|---|---|---|---|
MT tip localization | tip recognition | yes | yes | yes |
motility | bilateral diffusion | processivity | no | |
plus-end targeting | no | yes | yes | |
Mechanism of influencing MT dynamics | catastrophe factor | yes | yes | yes |
structural features | curls protofilaments | detects curved subunits | eliminates tip taper | |
method of MT disassembly | catastrophe | depolymerization by cooperative removal of subunits | catastrophe | |
Impact on MT aging | change number of MT aging steps | decreases | no change | decreases |
rate of catastrophe | no impact | accelerates | accelerates | |
Rescue events | no | no | no |