Table 1.
Baseline characteristics of all patients as well as stratified by mortality
| All patients (n=329) | No death (n=290) | Death (n=39) | P | |
|---|---|---|---|---|
| Demographic data | ||||
| Age (years) | 75 (65–82) | 74 (62–82) | 82 (78–87) | <0.001 |
| Women | 136 (41) | 119 (41) | 17 (44) | 0.86 |
| Medical history | ||||
| Hypertension | 251 (76) | 219 (76) | 32 (82) | 0.43 |
| Atrial fibrillation | 66 (20) | 49 (17) | 17 (44) | <0.001 |
| Current smoking | 116 (35) | 105 (36) | 11 (28) | 0.38 |
| Diabetes mellitus | 66 (20) | 57 (20) | 9 (23) | 0.67 |
| Coronary heart disease | 84 (26) | 69 (24) | 15 (38) | 0.08 |
| Dyslipidemia | 90 (27) | 79 (27) | 11 (28) | 0.85 |
| Previous cerebrovascular event | 80 (24) | 72 (25) | 8 (21) | 0.69 |
| Charlson comorbidity Index | 1 (0–2) | 1 (0–2) | 1 (0–2) | 0.04 |
| Infections at admission* | 21 (6.6) | 16 (5.7) | 5 (13.5) | 0.08 |
| Clinical data | ||||
| NIHSS at admission (points) | 5 (2–10) | 4 (2–8) | 15 (8–25) | <0.001 |
| Stroke syndrome and causative factors | ||||
| Total anterior circulation stroke | 35 (11) | 21 (7) | 14 (36) | <0.001 |
| Partial anterior circulation stroke | 150 (46) | 131 (45) | 19 (49) | 0.73 |
| Lacunar anterior circulation stroke | 67 (20) | 63 (22) | 4 (10) | 0.14 |
| Posterior circulation stroke | 89 (27) | 82 (28) | 7 (18) | 0.25 |
| Laboratory values | ||||
| Log-miR-150-5p† | 1,357.1 (755.8–2,869.3) | 1,452.9 (845.3–3,116.4) | 777.3 (577.7–1,326.4) | <0.001 |
| Glucose (mmol/L) | 6.1 (5.5–7.4) | 6.0 (5.4–7.4) | 6.3 (6.0–7.5) | 0.25 |
| CRP (mg/L)‡ | 3.5 (3.0–9.8) | 3.2 (3.0–8.6) | 14.0 (3.9–43.8) | <0.001 |
| White blood cells per µL | 8.3 (6.6–9.9) | 8.2 (6.6–9.7) | 9.3 (6.5–12.1) | 0.12 |
| Temperature (°C) | 37.0 (36.5–37.5) | 37.0 (36.5–37.4) | 37.2 (36.4–37.6) | 0.79 |
| Lesion size on MR, DWI§ | 1.7 (0.2-19.4) | 1.5 (0.2-16.4) | 40.0 (3.4-146.8) | 0.001 |
| Thrombolysis | 63 (19.8) | 54 (19.1) | 38 (20.0) | 0.26 |
| TOAST [15] subtype | ||||
| Large-vessel disease | 61 (19) | 56 (19) | 5 (13) | 0.39 |
| Cardioembolic | 121 (37) | 103 (36) | 18 (46) | 0.22 |
| Small-artery disease | 50 (15) | 49 (17) | 1 (3) | 0.02 |
| Other known | 15 (5) | 14 (5) | 1 (3) | 1.00 |
| Undetermined | 82 (25) | 68 (24) | 14 (36) | 0.11 |
| Time from symptom onset till blood draw | ||||
| 0–3 hours | 71 (21.9) | 59 (20.7) | 12 (30.8) | 0.15 |
| 3–12 hours | 169 (52.2) | 151 (52.98) | 18 (46.2) | 0.50 |
| 12–24 hours | 48 (14.8) | 45 (15.8) | 3 (7.7) | 0.23 |
| 24–72 hours | 36 (11.11) | 30 (10.5) | 6 (15.4) | 0.41 |
| 24–72 hours | 36 (11.11) | 30 (10.5) | 6 (15.4) | 0.41 |
Values are presented as median (meaning range between the first and third quartile) or number (%).
NIHSS, National Institute of Health Stroke Scale; CRP, C-reactive protein; MR, magnetic resonance; DWI, diffusion weighted imaging; TOAST, Trial of ORG 10172 in Acute Stroke Treatment.
All types of infections including pneumonia on admission or history within the last week;
Log10-transformed values were used, thus one-unit increase corresponds to a tenfold increase in normalized copy numbers per μL of plasma. See the “Statistical Analysis” section for details;
CRP had missing values (missing in 16.7% of patients);
Volume in milliliters. Refers to patients where information on diffusion-weighted imaging lesion was present (n=188).