Table 2.
Baseline characteristics of all patients, stratified by functional outcome
| All patients (n=329) | Favorable outcome (n=195) | Unfavorable outcome (n=134) | P | |
|---|---|---|---|---|
| Demographic data | ||||
| Age (years) | 75 (65–82) | 68.6 (20.4–94.2) | 78.0 (44.6–96.6) | <0.001 |
| Women | 136 (41) | 69 (35.4) | 67 (50.0) | <0.01 |
| Medical history | ||||
| Hypertension | 251 (76) | 142 (72.8) | 109 (81.3) | 0.09 |
| Atrial fibrillation | 66 (20) | 29 (14.9) | 37 (27.6) | <0.01 |
| Current smoking | 116 (35) | 74 (38.0) | 42 (31.3) | 0.24 |
| Diabetes mellitus | 66 (20) | 38 (19.5) | 28 (20.9) | 0.78 |
| Coronary heart disease | 84 (26) | 46 (23.6) | 38 (28.4) | 0.37 |
| Dyslipidemia | 90 (27) | 58 (29.7) | 32 (23.9) | 0.26 |
| Previous cerebrovascular event | 80 (24) | 45 (23.1) | 35 (26.1) | 0.60 |
| Charlson comorbidity Index | 1 (0–2) | 1 (0–8) | 2 (0–6) | <0.001 |
| Infections at admission* | 21 (6.6) | 9 (4.7) | 12 (9.5) | 0.11 |
| Clinical data | ||||
| NIHSS at admission (points) | 5 (2–10) | 5 (0–23) | 11 (0–42) | <0.001 |
| OCSP | ||||
| TACS | 35 (11) | 8 (4.1) | 27 (20.2) | <0.001 |
| PACS | 150 (46) | 87 (44.6) | 63 (47.0) | 0.74 |
| LACS | 67 (20) | 42 (21.5) | 25 (18.7) | 0.58 |
| POCS | 89 (27) | 61 (31.3) | 28 (20.9) | 0.04 |
| Laboratory values | ||||
| MiR-150-5p† | 1,357.1 (755.8–2,869.3) | 4,103.5 (185.4–180,811.3) | 1,980.3 (40.6–11,540.5) | 0.01 |
| Glucose (mmol/L) | 6.1 (5.5–7.4) | 6.6 (3.3–17.2) | 6.9 (2.2–24.6) | 0.10 |
| White blood cell per µL | 3.5 (3.0–9.8) | 8.2 (6.5-9.6) | 8.3 (6.7-10.2) | 0.20 |
| CRP (mg/L)‡ | 8.3 (6.6-9.9) | 9.9 (3.0–130.4) | 24.6 (3.0–302.0) | <0.001 |
| Temperature (°C) | 37.0 (36.5-37.5) | 37.0 (35.0-38.3) | 37.0 (35.3-39.9) | 0.56 |
| Lesion size on MR, DWI§ | 1.7 (0.2-19.4) | 12.2 (0.1-153.8) | 45.6 (0.1-317.5) | <0.001 |
| Thrombolyis | 63 (19.8) | 38 (20.0) | 25 (19.4) | 0.51 |
| TOAST [15] subtype | ||||
| Large-vessel disease | 61 (19) | 36 (18.5) | 25 (18.7) | 1.00 |
| Cardioembolic | 121 (37) | 70 (35.9) | 51 (38.1) | 0.73 |
| Small-artery disease | 50 (15) | 35 (18.0) | 15 (11.2) | 0.12 |
| Other known | 15 (5) | 10 (5.1) | 5 (3.7) | 0.60 |
| Undetermined | 82 (25) | 44 (22.6) | 38 (28.4) | 0.25 |
| Time from symptom onset till blood draw | ||||
| 0–3 hours | 71 (21.9) | 41 (21.5) | 30 (22.6) | 0.89 |
| 3–12 hours | 169 (52.2) | 97 (50.8) | 72 (54.1) | 0.57 |
| 12–24 hours | 48 (14.8) | 31 (16.2) | 17 (12.8) | 0.43 |
| 24–72 hours | 36 (11.11) | 22 (11.5) | 14 (10.5) | 0.86 |
Values are presented as median (meaning range between the first and third quartile) or number (%).
NIHSS, National Institute of Health Stroke Scale; OCSP, Oxfordshire Community Stroke Project; TACS, total anterior circulation syndrome; PACS, partial anterior circulation stroke; LACS, lacunar anterior circulation stroke; POCS, posterior circulation stroke; CRP, C-reactive protein; MR, magnetic resonance; DWI, diffusion weighted imaging; TOAST, Trial of ORG 10172 in Acute Stroke Treatment.
All types of infections including pneumonia on admission or history within the last week;
Normalized copy number per μL of plasma;
CRP had missing values (missing in 16.7% of patients);
Percentages refer to patients where information on DWI lesion was present (n=188).