Table 1.
Participant characteristics by genetic status
| Variable | GBA carriers (n = 28) | Noncarriers (n = 708) | p-value |
|---|---|---|---|
| Gender (%female) | 61% | 64.3% | 0.121a |
| Age at baseline, y, mean (SD) | 77.4 (5.6) | 78.5 (5.3) | 0.339b |
| Education, y, mean (SD) | 14.6 (3.8) | 14.0 (3.4) | 0.484b |
| Follow-up visits, mean (SD), median | 3.72 (1.85), 4 | 6.13 (3.80), 6 | 0.000b |
| Follow-up discontinued | 25 (89.3%) | 594 (83.9%) | 0.444a |
| Developed dementia | 7 (25.0%) | 107 (15.1%) | 0.156a |
| Developed PD | 1 (3.7%) | 11 (1.6%) | 0.408a |
| Deceased | 7 (25.0%) | 239 (33.8%) | 0.335a |
| Withdrew | 9 (32.1%) | 136 (19.2%) | 0.160a |
| Lost to follow up | 1 (3.7%) | 101 (14.3%) | 0.108a |
| FCSRT, mean (SD) | 32.0 (5.1) | 30.7 (6.3) | 0.172 |
| UPDRS-III, mean (SD) | 6.1 (6.0) | 7.8 (6.9) | 0.431 |
Key: FCSRT, free and cued selective reminding test; SD, standard deviation; UPDRS-III, Unified Parkinson’s Disease Rating Scale motor section; y, years.
a
Chi-squared test.
b
Mann Whitney U test.