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. 2017 Aug 28;14(5):4134–4140. doi: 10.3892/etm.2017.5051

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Copyright: © Yang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — BBR reducing the expression of inflammatory cytokine, chemokines and associated genes. Hepatic expression of (A) CXCR4 and (B) CXCL12 mRNA. (C) Representative slides illustrating CXCR4 and CXCL12-stained liver sections from the three experimental groups. Hepatic expression of (D) RAS, (E) PLC-β, (F) PI3K, (G) AKT, (H) NF-κβ, (I) IL-1 and (J) IL-8 mRNA was determined by quantitative polymerase chain reaction analysis and normalized to GAPDH. *P<0.05 vs. the HFHC group; ^∆P<0.05, ^∆∆P<0.01 vs. the BBR group. CXCR4, C-X-C chemokine receptor type 4; CXCL12, C-X-C motif chemokine 12; BBR, berberine; HFHC, high-fat high-cholesterol; SC, standard chow; PLC-β, phospholipase C-β; PI3K, phosphatidylinositol-3 kinase; AKT, protein kinase B; NF-κβ, nuclear factor-κβ; IL, interleukin.