Table 2.
Summarized oncologic results of included studies
| Name of study | Intervention | No. of patients | pCR (%) | 5-yr LRR (%) | 5-yr RFS (%) | 5-yr OS (%) | Sphincter-saving rate (%) | Severe acute toxicity (%) | Severe chronic toxicity (%) |
|---|---|---|---|---|---|---|---|---|---|
| Park et al. [9], 2011 | Preoperative CRT | 107 | 16.8 | 5.0 | 73.0 | 83.0 | 80.0 | 15.0 | 17.0 |
| Postoperative CRT | 113 | 0 | 6.0 | 74.0 | 85.0 | 72.0 | 16.0 | 15.0 | |
| Roh et al. [10], 2009 | Preoperative CRT | 123 | 14.6 | 10.7 | 64.7 | 74.5 | 47.8 | 41.2 | 25.0 |
| Postoperative CRT | 131 | 0 | 10.7 | 53.4 | 65.6 | 39.2 | 49.4 | 22.6 | |
| Sauer et al. [5], 2004 | Preoperative CRT | 405 | 7.9 | 6.0 | 68.0 | 76.0 | 69.0 | 27.0 | 14.0 |
| Postoperative CRT | 394 | 0 | 13.0 | 65.0 | 74.0 | 71.0 | 40.0 | 24.0 |
Numbers in bold represent statistically significant values.
pCR, pathologic complete response; LRR, locoregional recurrence; RFS, relapse-free survival; OS, overall survival; CRT, chemoradiotherapy.