Table 1.

EAE parameters in controls versus PLP:mtPstI mice after brief and transient induction of mtDNA DSBs

Group	Incidence	Onset (d)a	Peak disease (score)	Peak disease (d)	CDI
Controls	86.7% (13 of 15)	14.31 ± 0.89*	3.48 ± 0.11	15.58 ± 1.03**	78.64 ± 6.70
PLP:mPstI	72.7% (8 of 11)	20.63 ± 1.74	3.75 ± 0.37	20.63 ± 1.84	84.31 ± 14.35

^aOnset is considered as the day after the first disease manifestation; CDI = Cumulative Disease Index; n = 8–13/group.

*t₍₁₉₎ = 3.582, p = 0.0020, t test;

**t₍₁₈₎ = 2.584, p = 0.0187, t test.