Table 3.
Univariate analysis of risk factors of PZA resistant tuberculosis.
| Characteristic | PZA-S (n = 427) No. (%) |
PZA-R (n = 66) No. (%) |
PZA-R VS PZA-S
|
|
|---|---|---|---|---|
| OR (95% CI) | P value | |||
| Sex | ||||
| Male | 319 (86.0) | 52 (14.0) | 1 | |
| Female | 108 (88.5) | 14 (11.5) | 0.80 (0.40–1.53) | 0.47 |
| Age | ||||
| < 35 | 146 (86.4) | 23 (13.6) | 1 | |
| 35–55 | 156 (84.3) | 29 (15.7) | 1.18 (0.63–2.24) | 0.58 |
| >55 | 120 (90.9) | 12 (9.1) | 0.63 (0.28–1.40) | 0.22 |
| Unknown | 5 (71.4) | 2 (28.6) | 2.54 (0.23–16.56) | 0.27 |
| TB history | ||||
| New | 354 (91.7) | 32 (8.3) | 1 | |
| Re-treated | 58 (65.9) | 30 (34.1) | 5.72 (3.09–10.50) | <0.001 |
| Unknown | 15 (78.9) | 4 (21.1) | 2.95 (0.67–9.99) | 0.06 |
| Beijing strain | ||||
| No | 103 (92.0) | 9 (8.0) | 1 | |
| Yes | 324 (85.0) | 57 (15.0) | 2.01 (0.95–4.78) | 0.06 |
| Drug resistance profile | <0.001* | |||
| Pan-susceptibility | 194 (99.0) | 2 (1.0) | 1 | |
| INH mono-resistance | 126 (96.9) | 4 (3.1) | 3.08 (0.55–17.12) | 0.18 |
| RIF mono-resistance | 37 (86.0) | 6 (14.0) | 15.73 (2.85–86.8) | <0.001 |
| MDR | 54 (60.7) | 35 (39.3) | 62.9 (11.3–350.5) | <0.001 |
| Pre-XDR | 16 (45.7) | 19 (54.3) | 115.2 (14.5–912.6) | <0.001 |
| FQs resistance in MDR (n = 124) | ||||
| No | 54 (60.7) | 35 (39.3) | 1 | |
| Yes | 16 (45.7) | 19 (54.3) | 1.83 (0.77–4.36) | 0.13 |
Abbreviations: PZA, pyrazinamide; INH, isoniazid; RIF, rifampin; MDR, multidrug resistant.
*
P value for trend of chi-square test.