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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: Curr Sleep Med Rep. 2017 Apr 27;3(2):104–112. doi: 10.1007/s40675-017-0071-6

Figure 1.

Figure 1

Human pathophysiology due to shift work. In this paper, we discuss four broad components of health that are adversely affected by circadian misalignment due to shift work: heart health (top left quadrant), metabolic health (top right quadrant), cancer risk (bottom right quadrant), and mental health (bottom left quadrant). The inner circle represents biological systems that are disturbed by circadian misalignment, and the outer area represents broad psychosocial factors that interact with these disturbed biological systems. The ring between them illustrates key medical conditions that may arise from the interaction, for which shift workers are at elevated risk.