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| |||||||
|---|---|---|---|---|---|---|---|
| Cmpd | R1 | R2 | R3 | HAI EC>90 [nM] | Biofilm IC50 [nM] | DSF Temp [ °C] | |
| 21 | H | H | -- | 100 | -- | -- | |
| 22 | -- | -- | H | 250 | -- | -- | |
| 23 | CH3 | H | -- | 31 | 130 | 75.5 | |
| 24 | -- | -- | CH3 | 62 | 140 | 75.0 | |
| 26 | CH3 | CH2C(O)NH(3-pyridyl) | -- | 1 | 18 | -- | |
| 27 | CH3 | C(O)NH(3-pyridyl) | -- | 62 | -- | -- | |
| |||||||
| R1 | R2 | X-X | Binding IC50 [nM] | Aggregation IC50 [μM] | |||
| 28 | Cl | H | CH=CH | 14.9 | 8.3 | ||
| 29 | H | NO2 | CH2-CH2 | 20 | 26.9 | ||
| 30 | Cl | NO2 | CH2-CH2 | 2.4 | 3.4 | ||
