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. 2017 Nov;24(11):597–601. doi: 10.1101/lm.045898.117

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© 2017 Homan et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 2. — Planned contrasts for stimulus-discrimination differences between the prazosin and placebo groups for each session show effects specific for extinction and reextinction but not acquisition. Confidence intervals that do not include zero (cross the vertical dashed line) indicate that the corresponding contrast is statistically significant. Adjusted means (indicating the mean response for each factor, adjusted for any other variables in the model) with 95% confidence intervals for each drug, session, and stimulus were calculated from the multilevel model output and used to test the stimulus-discrimination (CS+ minus CS−) differences between prazosin and placebo for each session. Specifically, during acquisition, there was no significant group × stimulus interaction (t_(38.42) = −0.40, P = 0.69), and there was evidence across groups for significant stimulus discrimination (t_(38.42) = 4.07, P < 0.001). In contrast, when examining the subsequent stages, we found a significant group × stimulus interaction during extinction (t_(39.3) = 2.06, P = 0.046) and reextinction (t_(38.42) = 2.86, P = 0.006). (CS) Conditioned stimulus; (CI) confidence interval.