Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Nov;24(11):580–588. doi: 10.1101/lm.045773.117

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2017 Temme and Murphy; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

PMC Copyright notice

Figure 4. — Neuronal deletion of Ca_V1.2 results in an increase in sIPSC activity in principle neurons of the lateral amygdala. Representative recordings from wild-type (A₁) and Ca_V1.2 conditional knockout mice (A₂) of spontaneous IPSCs in inhibition onto principle neurons of the lateral amygdala using whole-cell voltage clamp. (B) Ca_V1.2 conditional knockout mice exhibited a significant change in sIPSC interevent interval cumulative distribution compared with wild-type mice. (C₁,C₂) Representation of the sIPSC interevent intervals using a histogram and a fitted Gaussian distribution, showed a leftward shift in Ca_V1.2 conditional knockout interevent intervals compared with wild-type mice. (D,E) Ca_V1.2 conditional knockout mice exhibited a significant decrease in the average sIPSC (n = 4884 events in 23 cells from seven mice) interevent interval compared with wild-type littermates (n = 3442 events in 19 cells from six mice), but no change in sIPSC amplitude. Data are represented as mean ± SEM. (*) P < 0.05.