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. 2017 Aug 15;31(16):1693–1703. doi: 10.1101/gad.302000.117

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© 2017 Maezawa et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 2. — PRC1 is required for timely activation of germline genes in spermatogonia. (A) The number of differentially expressed genes detected by RNA-seq (at least a 1.5-fold change) in Thy1⁺ and c-Kit⁺ spermatogonia (two biological replicates) between the PRC1ctrl and the PRC1cKO. (B) Venn diagrams showing the numbers of regulated genes between Thy1⁺ and c-Kit⁺ spermatogonia. (C) Representative down-regulated germline genes in Thy1⁺ spermatogonia of the PRC1cKO and their average reads per kilobase million (RPKM) values. (D) Fifteen representative germline genes among the top 50 down-regulated genes in c-Kit⁺ spermatogonia from the lowest P-values. (Left) P-values. (Right) Average RPKM values. P-values represent false discovery rate (FDR)-adjusted P-values by DESeq2. (E) Heat maps showing gene expression patterns of both up-regulated and down-regulated genes in c-Kit⁺ spermatogonia. Relative expression normalized to a range of −1 to 1 is shown.