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. Author manuscript; available in PMC: 2018 May 4.
Published in final edited form as: Cell. 2017 May 4;169(4):570–586. doi: 10.1016/j.cell.2017.04.004

Figure 2. Recent highlights in the restructuring of intracellular architecture and metabolism.

Figure 2

Immune cell function is a product of their metabolic state. Growth factor signaling, actin rearrangement, and glucose metabolism are closely intertwined. Actin-bound aldolase can be freed from the cytoskeleton downstream of growth factor signaling to mediate glycolysis. Engagement of this pathway is central to the activation and downstream effector functions of DCs, M1 macrophages, and T cells. T cells can dynamically restructure their mitochondria through processes like mitochondrial fission and fusion to signal changes in metabolism and to promote their long-term survival in the transition to memory cells.