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. 2017 Nov;23(11):1660–1671. doi: 10.1261/rna.062000.117

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© 2017 Donovan et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article is distributed exclusively by the RNA Society for the first 12 months after the full-issue publication date (see http://rnajournal.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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FIGURE 2. — Single-nucleotide resolution profiles of tRNA and Y-RNA cleavage during poly(IC) response. (A) Secondary structure cleavage profiles for Y-RNAs. RNase L targets the upper region at UN^N sites. RNY4 is cleaved predominantly at a single unconventional site CA^G. Stacked bar charts for RNA fragments are colored as in Figure 1E. (B) Graphic model of Y-RNA cleavage by RNase L. The main cleavage sites in all Y-RNAs are located in the region between nucleotides 24 and 32, away from the conserved binding sites for Ro60 and La autoantigens. (C) Secondary structure cleavage profiles for RNase L-sensitive tRNAs. (D) Graphic model for tRNA cleavage by RNase L versus ANG and bacterial endoribonucleases.