Fig. 5.

Dasatinib does not affect psychomotor stimulation by morphine. (A) The graph of locomotion averaged over 3 days of conditioning with dasatinib and/or morphine. Dasatinib had no effect on locomotion when administered alone to wild type mice (n = 8). Dasatinib (n = 8) also had no effect compared to vehicle (n = 8) on the stimulation of locomotion by morphine, which was significant in both cases (*p < 0.001, paired t-test). (B) Dasatinib (5 mg/Kg) was without effect on distance travelled by mice (n = 8) on all 3 days of conditioning. (C) Morphine caused locomotor stimulation with sensitization over the 3 days of conditioning when mice were administered either vehicle (left panel) or dasatinib (right panel) i.p (*p < 0.0001, two-way ANOVA, post hoc Bonferroni test).