(2) Clinical Symptoms.
| At the Start of Treatment |
Entire Period |
|||||
|---|---|---|---|---|---|---|
| Thyroid Cancer (−) | Thyroid Cancer (+) | P | Thyroid Cancer (−) | Thyroid Cancer (+) | P | |
| Butterfly rash | 11/26 | 1/3 | 1 | 16/26 | 3/3 | .532 |
| Discoid papulosis | 1/26 | 0/3 | 1 | 1/26 | 0/3 | 1 |
| Photosensitivity | 5/26 | 0/3 | 1 | 5/26 | 0/3 | 1 |
| Oral, nasal, or mucosal painless ulcer | 8/26 | 2/3 | .267 | 9/26 | 3/3 | .062 |
| Hair loss | 1/26 | 0/3 | 1 | 4/26 | 1/3 | .446 |
| Raynaud’s phenomenon | 3/26 | 0/3 | 1 | 4/26 | 0/3 | 1 |
| Peptic ulcer | 0/26 | 0/3 | 1 | 4/26 | 0/3 | 1 |
| Other skin conditions | 3/25 | 2/3 | .0733 | 1/25 | 2/3 | .0232 |
| Convulsion | 3/26 | 0/3 | 1 | 3/26 | 0/3 | 1 |
| Psychological symptom | 3/26 | 0/3 | 1 | 3/26 | 0/3 | 1 |
| Organic brain syndrome | 1/25 | 0/3 | 1 | 1/25 | 0/3 | 1 |
| Cranial nerve symptoms | 1/25 | 0/3 | 1 | 0/25 | 0/3 | 1 |
| Mononeuritis multiplex | 1/25 | 0/3 | 1 | 0/25 | 0/3 | 1 |
| Disturbance of consciousness | 2/26 | 0/3 | 1 | 2/26 | 0/3 | 1 |
| Cerebrovascular disorder | 0/26 | 0/3 | 1 | 0/26 | 0/3 | 1 |
| Spinal disorder | 0/26 | 0/3 | 1 | 0/26 | 0/3 | 1 |
| Aseptic meningitis | 0/26 | 0/3 | 1 | 0/26 | 0/3 | 1 |
| Other neurological symptoms | 1/25 | 0/3 | 1 | 2/25 | 0/3 | 1 |
| Nondestructive arthritis (more than two) | 12/26 | 2/3 | .598 | 12/26 | 2/3 | .598 |
| Muscle pain | 2/26 | 0/3 | 1 | 5/26 | 0/3 | 1 |
| Muscle weakness | 3/26 | 0/3 | 1 | 3/26 | 0/3 | 1 |
| Pleurisy | 0/26 | 0/3 | 1 | 1/26 | 0/3 | 1 |
| Epicarditis | 1/26 | 0/3 | 1 | 3/26 | 0/3 | 1 |
| Interstitial pneumonia | 0/26 | 0/3 | 1 | 1/26 | 0/3 | 1 |
| Pulmonary hypertension | 0/26 | 0/3 | 1 | 0/26 | 0/3 | 1 |
| Pulmonary infarction | 0/26 | 0/3 | 1 | 0/26 | 0/3 | 1 |
| Pulmonary hemorrhage | 0/26 | 0/3 | 1 | 0/26 | 0/3 | 1 |
| Other cardiopulmonary symptoms | 0/25 | 0/3 | 1 | 0/25 | 0/3 | 1 |
| Rapidly progressive nephritis | 0/26 | 0/3 | 1 | 0/26 | 0/3 | 1 |
| Acute renal failure | 0/26 | 0/3 | 1 | 0/26 | 0/3 | 1 |
| Chronic renal failure | 0/26 | 0/3 | 1 | 0/26 | 0/3 | 1 |
| Nephrotic syndrome | 0/26 | 0/3 | 1 | 0/26 | 0/3 | 1 |
| Renal biopsy abnormal | 5/7 | 2/2 | 1 | 10/11 | 1/1 | 1 |
| Other renal symptoms | 1/25 | 1/3 | .206 | 2/26 | 0/3 | 1 |
| Fever | 18/25 | 3/3 | .551 | 20/26 | 3/3 | 1 |
| Weight loss | 6/26 | 1/3 | 1 | 6/26 | 3/3 | .023 |
| Lymphadenopathy, splenomegaly | 8/26 | 3/3 | .0452 | 8/26 | 3/3 | .045 |
| Easy fatigability, general malaise, weakness | 12/26 | 2/3 | .598 | 13/26 | 2/3 | 1 |
| Loss of appetite, nausea, and vomiting | 12/26 | 2/3 | .598 | 12/26 | 3/3 | .224 |