. 2017 Oct 19;12(10):e0186050. doi: 10.1371/journal.pone.0186050

Table 2. Age- and sex-adjusted odds ratios (95% confidence intervals) of surrogate markers predicting metabolic syndrome and cardiometabolic risk factor (CMRF) clustering.

Category	Surrogate markers	Total	10–15 years	16–19 years	Boys	Girls
Metabolic syndrome	HbA1c (%)	1.8 (1.3–2.6)^**	1.8 (1.3–2.7)^**	1.7 (0.9–3.3)	3.88 (0.91–16.4)^**	1.59 (1.08–2.35)^**
	TG/HDL-C ratio	2.3 (1.8–3.0)^**	1.9 (1.3–2.8)^**	3.1 (2.1–4.5)^**	2.11 (1.31–3.39)^**	2.56 (2.00–3.28)^**
	Non-HDL-C (mg/dL)	1.04 (1.03–1.05)^**	1.03 (1.02–1.05)^**	1.04 (1.03–1.06)^**	1.03 (1.02–1.05)^**	1.05 (1.03–1.06)^**
	ALT (IU/L)	1.03 (1.02–1.05)^**	1.03 (1.02–1.04)^**	1.05 (1.03–1.07)^**	1.03 (1.02–1.04)^**	1.06 (1.03–1.10)^**
	WHtR (%)	1.4 (1.3–1.5)^**	1.4 (1.3–1.5)^**	1.4 (1.3–1.5)^**	1.37 (1.28–1.46)^**	1.48 (1.35–1.62)^**
	BMI z-score	11.4 (7.3–17.8)^**	13.5 (6.7–27.2)^**	10.5 (5.6–19.7)^**	15.4 (7.1–33.3)^**	8.9 (5.1–15.6)^**
CMRF clustering	HbA1c (%)	2.1 (1.1–4.0)^**	2.0 (0.9–4.7)	2.0 (0.8–5.2)	3.7 (1.7, 7.9)^**	1.7 (1.0–3.0)^*
	TG/HDL-C ratio	3.9 (3.3–4.6)^**	4.2 (3.4–5.3)^**	4.1 (3.1–5.3)^**	3.7 (3.0–4.5)^**	4.6 (3.4–6.1)^**
	Non-HDL-C (mg/dL)	1.03 (1.03–1.04)^**	1.04 (1.03–1.04)^**	1.03 (1.02–1.04)^**	1.03 (1.02–1.04)^**	1.03 (1.02–1.04)^**
	ALT (IU/L)	1.05 (1.03–1.06)^**	1.05 (1.02–1.07)^**	1.05 (1.04–1.06)^**	1.04 (1.03–1.05)^**	1.06 (1.02–1.11)^**
	WHtR (%)	1.3 (1.3–1.4)^**	1.3 (1.2–1.4)^**	1.3 (1.2–1.4)^**	1.3 (1.2–1.4)^**	1.3 (1.3–1.4)^**
	BMI z-score	4.1 (3.2–5.2)^**	4.7 (3.4–6.5)^**	3.6 (2.6–5.1)^**	4.6 (3.1–6.9)^**	3.6 (2.6–4.9)^**

*P <0.05,

**P <0.01

HbA1c: glycated hemoglobin; TG/HDL-C: triglyceride to high density lipoprotein cholesterol; ALT: alanine transaminase; WHtR: Waist circumference to height ratio; BMI: Body mass index.