Table 3. Area under the curve (95% confidence intervals) and cut-off values of surrogate markers for predicting metabolic syndrome and cardiometabolic risk factor (CMRF) clustering.
| Category | Surrogate markers | Total | 10–15 years | 16–19 years | Boys | Girls | Cut-off value | Sensitivity (%) | Specificity (%) |
|---|---|---|---|---|---|---|---|---|---|
| Metabolic syndrome (IDF) | HbA1c (%) | 0.627 (0.625, 0.629) | 0.637 (0.635, 0.639) | 0.624 (0.621, 0.627) | 0.621 (0.618, 0.623) | 0.633 (0.630, 0.636) | 5.5 | 70.5 | 50.5 |
| TG/HDL-C ratio | 0.947 (0.946, 0.948) | 0.965 (0.964, 0.965) | 0.936 (0.934, 0.937) | 0.934 (0.932, 0.935) | 0.963 (0.962, 0.964) | 2.64 | 95.1 | 86.4 | |
| Non-HDL-C (mg/dL) | 0.779 (0.778, 0.781) | 0.747 (0.745, 0.749) | 0.808 (0.806, 0.810) | 0.735 (0.733, 0.737) | 0.844 (0.842, 0.845) | 111.6 | 81.3 | 63.7 | |
| ALT (IU/L) | 0.820 (0.819, 0.822) | 0.816 (0.814, 0.818) | 0.822 (0.820 0.823) | 0.867 (0.865, 0.868) | 0.811 (0.809, 0.813) | 21 | 63.5 | 88.2 | |
| WHtR | 0.960 (0.959, 0.960) | 0.954 (0.953, 0.954) | 0.964 (0.963, 0.964) | 0.967 (0.967, 0.968) | 0.957 (0.957, 0.957) | 0.491 | 96.5 | 88.2 | |
| BMI z-score | 0.959 (0.957, 0.962) | 0.957 (0.956, 0.957) | 0.962 (0.961, 0.962) | 0.966 (0.966, 0.966) | 0.955 (0.954, 0.955) | 1.35 | 95.1 | 89.4 | |
| CMRF clustering | HbA1c (%) | 0.607 (0.606, 0.608) | 0.596 (0.594, 0.597) | 0.628 (0.627, 0.629) | 0.580 (0.578, 0.581) | 0.636 (0.634, 0.637) | 5.6 | 50.0 | 66.8 |
| TG/HDL-C ratio | 0.891 (0.891, 0.892) | 0.917 (0.916, 0.918) | 0.869 (0.868, 0.869) | 0.898 (0.898, 0.899) | 0.885 (0.884, 0.885) | 2.63 | 74.4 | 90.5 | |
| Non-HDL-C (mg/dL) | 0.720 (0.719, 0.721) | 0.716 (0.715, 0.717) | 0.725 (0.724, 0.726) | 0.708 (0.707, 0.709) | 0.738 (0.737, 0.739) | 118.7 | 60.1 | 75.2 | |
| ALT (IU/L) | 0.730 (0.729, 0.730) | 0.780 (0.779, 0.781) | 0.686 (0.685, 0.687) | 0.798 (0.797, 0.799) | 0.704 (0.702, 0.705) | 15 | 61.8 | 74.4 | |
| WHtR | 0.842 (0.841, 0.843) | 0.843 (0.842, 0.844) | 0.840 (0.839, 0.841) | 0.857 (0.856, 0.858) | 0.829 (0.828, 0.830) | 0.469 | 74.1 | 82.9 | |
| BMI z-score | 0.829 (0.828, 0.830) | 0.839 (0.838, 0.840) | 0.821 (0.820, 0.822) | 0.853 (0.852, 0.854) | 0.804 (0.803, 0.805) | 1.06 | 68.2 | 87.2 |
All P values were <0.001 when compared AUC between age groups and sex.
HbA1c: glycated hemoglobin; TG/HDL-C: triglyceride to high density lipoprotein cholesterol; ALT: alanine transaminase; WHtR: waist circumference to height ratio; BMI: body mass index.