Table 1. Demographic characteristics, clinical features, and resource utilizations of patients with invasive aspergillosis pneumonia (N = 407).
| Variables -Number (%) | Total (N = 407) | Survival (N = 284) | In-hospital death (N = 123) | P value |
|---|---|---|---|---|
| Gender | ||||
| Female | 150 (36.86) | 101 (35.56) | 49 (39.84) | 0.4118 |
| Male | 257 (63.14) | 183 (64.44) | 74 (60.16) | |
| Age, years | ||||
| 0–18 | 34 (8.35) | 31 (10.92) | 3 (2.44) | <0.0001 |
| 19–49 | 121 (29.73) | 90 (31.69) | 31 (25.20) | |
| 50–64 | 117 (28.75) | 87 (30.63) | 30 (24.39) | |
| 65+ | 135 (33.17) | 76 (26.76) | 59 (47.97) | |
| mean±SD | 53.15±20.93 | 50.46±21.01 | 59.36±19.46 | <0.0001 |
| GM test | 125 (30.71) | 84 (29.58) | 41 (33.33) | 0.4507 |
| Bronchoscopy | 128 (31.45) | 75 (26.41) | 53 (43.09) | 0.0009 |
| Computered tomography | 300 (73.71) | 207 (72.89) | 93 (75.61) | 0.5667 |
| Use of intubation and MV | 136 (33.42) | 45 (15.85) | 91 (73.98) | <0.0001 |
| ICU admission | 147 (36.12) | 59 (20.77) | 88 (71.54) | <0.0001 |
| Length of stay, days- Median (IQR) | ||||
| Overall | 35 (21–54) | 35.0 (20.5–52.5) | 33.0 (21.0–56.0) | 0.4297 |
| In ICU admission | 11 (5–22) | 8.0 (2.0–18.0) | 14 (6.0–24.5) | 0.0062 |
| Medical cost, US dollars- Median (IQR) | 15045 (7127–27743) | 13120 (5983–25836) | 19729 (10919–34599) | <0.0001 |
| Comorbidity | ||||
| DM | 75 (18.43) | 45 (15.85) | 30 (24.39) | 0.0412 |
| ESRD | 14 (3.44) | 9 (3.17) | 5 (4.07) | 0.6488 |
| Liver cirrhosis | 25 (6.14) | 20 (7.04) | 5 (4.07) | 0.2507 |
| COPD | 41 (10.07) | 22 (7.75) | 19 (15.45) | 0.0178 |
| Asthma | 25 (6.14) | 18 (6.34) | 7 (5.69) | 0.8029 |
| Bronchiectasis | 19 (4.67) | 14 (4.93) | 5 (4.07) | 0.7042 |
| Tuberculosis | 40 (9.83) | 29 (10.21) | 11 (8.94) | 0.6931 |
| AIDS | 4 (0.98) | 2 (0.70) | 2 (1.63) | 0.5876 |
| Autoimmune disease | 27 (6.63) | 17 (5.99) | 10 (8.13) | 0.4248 |
| Cancer | ||||
| Solid organ cancer | 59 (14.50) | 39 (13.73) | 20 (16.26) | 0.5059 |
| Hematological cancer | 216 (53.07) | 163 (57.39) | 53 (43.09) | 0.0079 |
| Transplantation | ||||
| No | 386 (94.84) | 270 (95.07) | 116 (94.31) | 0.3809 |
| Bone marrow transplantation | 8 (1.97) | 4 (1.41) | 4 (3.25) | |
| Organ transplantation | 13 (3.19) | 10 (3.52) | 3 (2.44) | |
| During the hospitalization | ||||
| Other infectious diseases | 171 (42.01) | 104 (36.62) | 67 (54.47) | 0.0008 |
| Acute renal failure | 20 (4.91) | 6 (2.11) | 14 (11.38) | <0.0001 |
| Use of voriconazole | ||||
| No | 125 (30.71) | 83 (29.23) | 42 (34.15) | 0.3230 |
| Yes | 282 (69.29) | 201 (70.77) | 81 (65.85) | |
| Use of steriod | ||||
| No | 76 (18.67) | 69 (24.30) | 7 (5.69) | <0.0001 |
| Yes | 331 (81.33) | 215 (75.70) | 116 (94.31) |
SD: standard deviation. IQR: inter-quartile range. MV: mechanical ventilator