Table 1. Summary of pupil light reflex parameters and ocular characteristics between patients with optic neuritis and nonarteritic anterior ischemic optic neuropathy in the acute phase and controls.
| ON (N = 30) | Age-matched Control of ON (N = 36) |
P Value | NAION (N = 22) | Age-matched Control of NAION (N = 22) |
P Value | |
|---|---|---|---|---|---|---|
| M:F (N) | 10:20 | 16:20 | 0.361* | 13:9 | 10:12 | 0.371* |
| Laterality (R:L) | 14:16 | 36:0 | 12:10 | 22:0 | ||
| Symptom duration (day) | 7.5±5.3 (1,20) | 18.5±13.1 (1,43) | ||||
| Age (year) | 38.3±16.5 (7.3,70.6) | 40.0±16.9 (7.3,69.1) | 0.675 | 59.5±11.6 (37.9,80.8) | 60.0±11.7(36.9,78.3) | 0.888 |
| Visual acuity (LogMAR) | 1.08±0.75 (-0.17,2.00) | 0.01±0.05 (-0.10,0.08) | <0.001 | 0.93±0.61 (0.10,2.00) | -0.08±0.19 (-0.50,0.18) | <0.001 |
| Visual field MD (dB) | -10.01±8.51 (-28.68,-1.45) | -0.95±1.48 (-4.19,1.27) | 0.008 | -16.07±6.51 (-26.58,-4.68) | -1.35±1.45 (-5.12,0.52) | <0.001 |
| Average RNFL thickness (μm) | 139.3±43.8 (71,238) | 102.6±7.6 (85,116) | <0.001 | 156.8±70.0 (70,283) | 103.1±7.0 (86,111) | 0.007 |
| Temporal RNFL thickness (μm) | 94.2±24.7 (56,162) | 79.9±12.8 (64,117) | 0.009 | 126.5±75.8 (41,251) | 77.7±21.0 (57,131) | 0.171 |
| PMB RNFL thickness (μm) | 64.6±12.5 (43,87) | 59.0±9.1 (43,80) | 0.077 | 102.3±78.1 (31,286) | 54.3±13.7 (39,90) | 0.164 |
| Red-green color defect (N)† | 4:6:2:0:18 | 36:0:0:0:0 | <0.001 | 10:6:0:0:6 | 22:0:0:0:0 | <0.001 |
| Blue-yellow color defect (N)† | 2:6:3:1:18 | 36:0:0:0:0 | <0.001 | 8:5:0:3:6 | 22:0:0:0:0 | <0.001 |
| Maximal pupil diameter (mm) | 5.5±0.7 (4.0,7.2) | 5.7±0.9 (3.7,7.2) | 0.241 | 5.1±1.0 (2.9,6.5) | 5.4±1.0 (3.6,6.8) | 0.155 |
| Minimal pupil diameter (mm) | 4.4±0.8 (3.0,6.2) | 3.9±0.7 (2.4,5.2) | 0.019 | 3.9±1.0 (2.1,5.5) | 3.7±0.8 (2.3,5.1) | 1.000 |
| Pupil constriction ratio (%) | 19.8±10.4 (1,36) | 31.4±3.4 (26,41) | <0.001 | 23.8±7.6 (10,34) | 32.4±3.5 (26,40) | <0.001 |
| Latency (sec) | 0.28±0.06 (0.19,0.43) | 0.23±0.02 (0.19,0.25) | <0.001 | 0.26±0.02 (0.22,0.28) | 0.23±0.02 (0.19,0.25) | <0.001 |
| ACV (mm/s) | 2.56±1.18 (0.10,4.40) | 3.77±0.43 (2.54,4.47) | <0.001 | 2.76±0.73 (1.75,3.99) | 3.69±0.46 (2.73,4.49) | <0.001 |
| MCV (mm/s) | 3.33±1.55 (0.38,5.03) | 4.87±0.52 (3.41,5.84) | <0.001 | 3.32±1.18 (0.67,5.05) | 4.75±0.54 (3.54,5.51) | <0.001 |
| ADV (mm/s) | 0.72±0.28 (0.20,1.20) | 0.92±0.15 (0.60,1.19) | 0.001 | 0.74±0.22 (0.39,1.29) | 0.95±0.19 (0.50,1.27) | 0.002 |
| T75 (sec) | 1.63±0.80 (0.97,3.55) | 1.92±0.63 (1.02,2.00) | 0.001 | 1.73±0.66 (0.83,3.52) | 1.35±1.45 (0.52,5.12) | 0.352 |
ACV, Average constriction velocity; ADV, Average dilation velocity; MD, mean deviation; NAION, nonarteritic ischemic optic neuropathy; ON, optic neuritis; PMB, papillomacular bundle; RNFL, retinal nerve fiber layer; T75, Total time from the peak of constriction to recovery of the pupil to 75% of maximal pupil diameter
Continuous variables are given as mean with standard deviations (range).
P values by independent t-test for continuous variables.
*P value by Chi-square test.
Factors with statistical significance are shown in boldface.
†The number of patients showing the following results by the HRR color vision test: ‘Normal:Mild:Moderate:Severe:Demonstration failure’.