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. 2017 Oct 19;12(10):e0186717. doi: 10.1371/journal.pone.0186717

Table 2. MR detection thresholds of SPIO-labeled stem cells in live animal brain.

Reference Type of cells, labels used and cells delivery method MR system type and pulse sequence Minimum number of cells detected and cells/μl detected
This study hMSCs from placenta—SPIO microspheres (MC03F, Bangs Laboratories, USA)—Intracerebral Experimental 7T - SWI 1x102 / 5 in 1 μl
This study hMSCs from placenta—SPIO microspheres (MC03F, Bangs Laboratories, USA)—Intra-arterial Experimental 7T - SWI Single cell
Ariza de Schellenberger et al.[13] Murine MSCs—Two types of hanmade SPIO and Resovist® (Resovist®, Bayer Healthcare, Germany)—Intra-arterial Experimental 7T with CryoProbe™ - SWI Single cell
Stroh et al.[15] Mouse embryonic stem cells—Very small SPIO particles (VSOP) C200 (Ferro Pharma, Germany)—Intra-arterial Experimental 17.6T - T2* 1x102 / 50 in 1 μl
Park et al.[22] hMSCs from bone marrow—Feridex® SPIO nanoparticles (Bayer Healthcare Pharmaceuticals, USA)—Intracerebral Clinical 3T - SWI 2x102 / 13 in 1 μl
Jendelová et al.[46] Rat MSCs from bone marrow—Endorem® SPIO nanoparticles (Guerbet GmbH, Germany)—Intracerebral Experimental 4.7T - T2* - / 625 in 1 μl
Yin et al.[47] Human adipose-derived stem cells—Ferumoxytol/Feraheme SPIO (AMAG Pharmaceuticals, USA)—Intracerebral Clinical 3T - SWI (SWAN) 1x104 / 2 000 in 1 μl
Hu et al.[12] hMSCs from umbilical cord—handmade SPIO nanoparticles (80nm mean diameter)—In to the spinal cord Experimental 7T - T2 1x105 / 4 000 in 1 μl
Argibay et al.[41] Rat MSCs—handmade coated magnetic nanoparticles (8.6±1.4 nm mean diameter)—Intracerebral Experimental 9.4T - T2* 5x104 / 5 000 in μl
Umashankar et al.[42] Rat neural stem cell—MIRB (USPIO-based contrast reagent BioPAL Inc., USA)—Intracerebral Experimental 7T - T2* 5x104 / 50 000 in 1 μl
Cheng et al.[20] hMSCs from bone marrow—Resovist® SPIO nanoparticles (Bayer Healthcare Pharmaceuticals, USA)—Intracerebral Clinical 3T - SWI 5x107 / 10 000 000 in 1 μl
Magnitsky et al.[36] Mouse neural stem cells—Feridex® SPIO nanoparticles (Bayer Healthcare Pharmaceuticals, USA)—Intracerebral Experimental 4.7T - T2* 5x102 /
Zhu et al.[48] Rat neural stem cells—Endorem® SPIO nanoparticles (Guerbet GmbH, Germany)—Intracerebral Experimental 4.7T - T2* 1x106 /