Figure 6.

Graphical representation summarizing the nutrient-induced effect on the mode of proliferation. (a) Fed mice in vivo or high glucose in vitro inhibits the phosphorylation of AMPK (pAMPK) and results in vertical cleavage and symmetric division. (b) Metformin, an activator of AMPK, blocks the high glucose-induced effect in vitro and results in horizontal cleavage and asymmetric division. (c) Fasted mice in vivo or no glucose in vitro stimulates the phosphorylation of AMPK and results in horizontal cleavage and asymmetric division. (d) Compound C, an inhibitor of pAMPK, blocks the no glucose-induced effect in vitro and results in vertical cleavage and symmetric division