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. 2017 Oct 13;12:7469–7482. doi: 10.2147/IJN.S139775

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© 2017 Cai et al. This work is published and licensed by Dove Medical Press Limited

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Tissue-selective distribution and cell-selective delivery of miRNA by Asp⁸-PU in vivo.

Notes: (A) Tissue-selective distribution of siRNA delivered by Asp⁸-PU in mouse organs. (B) Representative fluorescence micrography of proximal tibiae from mice treated with PU-Cy³-miR214 or Asp⁸-PU-Cy³-miR214. The Cy³-miR214 signal was red, and the bone-formation surfaces were labeled with calcein (green). Bars 100 μm. (C) Immunohistostaining was performed to detect CTSK-positive cells (green). Merged images with DAPI staining showed colocalization of Cy³-miR214 and CTSK-positive cells. Bars 100 μm.

Abbreviations: DAPI, 4′,6-diamidino-2-phenylindole or dihydrochloride; PU, polyurethane.