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. 2017 Oct 13;12:7469–7482. doi: 10.2147/IJN.S139775

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© 2017 Cai et al. This work is published and licensed by Dove Medical Press Limited

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Antiosteoporosis efficacy of Asp⁸-PU–anti-miR214.

Notes: *P<0.05. (A) Real-time qPCR analysis of miR214 levels in osteoclasts isolated by FACS in tibiae collected from the groups of mice indicated; (B) representative images showing three-dimensional trabecular architecture by micro-CT reconstruction in distal femora (bars 1 mm); (C) micro-CT measurements of BMD and BV/TV in distal femora; (D) micro-CT measurements of Tb.Th, Tb.Sp, Tb.N, and SMI in distal femora; (E) histomorphometry analysis of Oc.S/BS and Oc.N/BPm in distal femora. All data presented as means ± SE, n=6 per group. **Indicates significant difference at P<0.01.

Abbreviations: PU, polyurethane; qPCR, quantitative polymerase chain reaction; FACS, fluorescence-activated cell sorting; CT, computed tomography; BMD, bone-mineral density; BV, bone volume; TV, total volume; Tb.Th, trabecular thickness; Tb.Sp, Tb spacing; Tb.N, Tb number; SMI, structure model index; Oc.S/BS, osteoclast surface/bone surface; Oc.N/BPm, Oc number/bone perimeter; Ovx, ovariectomized; NC, anti-scramble group.