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Increased td-TGF-β allows tumor growth under high immune pressure, with later growth suppression and eradication.
CT26-neo or CT26-TGF-β cells were implanted (106/mouse) in the right flank of allogeneic C57B/6 mice and early tumor establishment was observed only in CT26-TGF-β and not in CT26-neo mice (n=5 per group). However, tumors were eradicated by day 21.
