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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 Apr 20;2(7):599–609. doi: 10.1016/j.bpsc.2017.04.002

Figure 3.

Figure 3

Tat protein exposure reduces saccharin, but not water consumption in a two-bottle assay. Daily consumption (ml/d) of saccharin (left panel) or water (right panel) shown 6d prior to drug administration, during daily saline (white circles, N=16) or Dox (100 mg/kg/d, i.p.; black squares, N=16) treatment for 7d, and for 5 days thereafter. *= p<0.05 vs. matching response of saline-treated (uninduced) mice of same day. Effect sizes (Cohen’s ds) for significantly different paired time points ranged from 1.18 to 1.72.